Trials we participate in are Phase II and Phase III, no Phase 1. Examples of trials we have been involved in are: Breast, Rectal, Gastric, Leukemia, Lymphoma, Lung, Sarcoma, Carcinoid, Prostate, Renal, Ovarian, Myeloma, Melanoma, Pancreas, Brain, Hepatoma, Head and Neck, Uterine and Prostrate Prevention. We also participate in Biospecimen protocols, registries, and quality of life studies.
Clinical trials are research studies that involve people. They are the final step in a long process that begins with research in a lab. Many treatments used today are the result of past clinical trials.
In cancer research, clinical trials are designed to answer questions about new ways to:
- Treat Cancer
- Find and diagnose cancer
- Prevent cancer
- Manage symptoms of cancer or its treatment
Clinical trials take place in phases. For a treatment to become part of standard treatment, it must first go through 3 or 4 clinical trial phases. You do not have to take part in all phases. The early phases make sure the treatment is safe. Later phases show if it works better than the standard treatment.
The purpose of Phase I trials is to find safe doses, to decide how the new treatment should be given and to see how the new treatment affects the human body. Usually 13-30 people take part in a study of this nature.
Phase II trials determine if the new treatment has an effect on a certain cancer and evaluates how the new treatment affects the human body. Usually less than 100 people take part in these studies.
Phase III trials compare the new treatment (or new use of a treatment) with the current standard treatment. These trials enroll from 100 to thousands of people.
The Cancer Centers of Southwest Oklahoma only participates in Phase II and III clinical trials.
Placebo – A placebo is de-signed to look like the medicine being tested, but it is not active. In some cases, a study may com-pare standard treatment plus a new treatment, to standard treatment plus a placebo. You will be told if the study uses a placebo.
Randomization – Randomization is a process used in some clinical trials to prevent bias. Bias occurs when a trial’s results are affected by human choices or other factors not related to the treatment being tested.
Benefits of a Clinical Trial:
Clinical trials offer high-quality cancer care. If you are in a randomized study and do not receive the new treatment being tested, you will receive the best known standard treatment. This may be as good as, or better than, the new approach.
If a new treatment is proven to work and you are taking it, you may be among the first to benefit.
You have the chance to help others and improve cancer treatment.